abstract：:Pancreatic cancer is the fourth leading cause of cancer death. Soluble receptor for glycation end products (sRAGE), which is modulated by anti-hypertensive (HT) medications, has been inversely associated with pancreatic cancer. However, the association between commonly used anti-HT medications and risk of pancreatic c...

journal_title：Journal of clinical medicine

authors： Wang Z,White DL,Hoogeveen R,Chen L,Whitsel EA,Richardson PA,Virani SS,Garcia JM,El-Serag HB,Jiao L

更新日期：2018-08-02 00:00:00

abstract：:The relation between vitamin-D (VD) status and healing after hip fracture had not been sufficiently addressed. Currently serum total 25-hydroxy-VD (t-25OHD) is the most widely used indicator of VD status. It is unclear whether free or bioavailable VD are better markers of 25OHD availability for tissues. Validity of ov...

journal_title：Journal of clinical medicine

authors： Toldy E,Salamon A,Kálmán B,Ágota K,Horváth D,Lőcsei Z

更新日期：2018-08-01 00:00:00

abstract：:This article evaluates the psychometric properties of a new measure for assessing Substance-Related and Addictive Disorders: the Addictive Behavior Questionnaire (ABQ). The ABQ is a self-report measure composed of two sections: the Severity Index (SI) and the Seven Domains Addiction Scale (7DAS). MATERIALS AND METHOD...

journal_title：Journal of clinical medicine

authors： Caretti V,Gori A,Craparo G,Giannini M,Iraci-Sareri G,Schimmenti A

更新日期：2018-08-01 00:00:00

abstract：:Preterm birth (PTB, <37 weeks) is the leading cause of death in children <5 years of age. Early risk prediction for PTB would enable early monitoring and intervention. However, such prediction models have been rarely reported, especially in low- and middle-income areas. We used data on a number of easily accessible pr...

journal_title：Journal of clinical medicine

authors： He JR,Ramakrishnan R,Lai YM,Li WD,Zhao X,Hu Y,Chen NN,Hu F,Lu JH,Wei XL,Yuan MY,Shen SY,Qiu L,Chen QZ,Hu CY,Cheng KK,Mol BWJ,Xia HM,Qiu X

更新日期：2018-07-27 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is a common condition, affecting 5⁻10% of women of reproductive age worldwide. It has serious reproductive implications and causes mood disorders and metabolic disorders, such as type-2 diabetes. Because PCOS reflects multiple abnormalities, there is no single drug that can treat all i...

journal_title：Journal of clinical medicine

authors： Liao WT,Chiang JH,Li CJ,Lee MT,Su CC,Yen HR

更新日期：2018-07-22 00:00:00

abstract：:It is now widely established that management of lung cancer is much more complex and cannot be centered on the binary classification of small-cell versus non-small cell lung cancer (NSCLC). Lung cancer is now recognized as a highly heterogeneous disease that develops from genetic mutations and gene expression patterns...

journal_title：Journal of clinical medicine

authors： Ahmadzada T,Kao S,Reid G,Boyer M,Mahar A,Cooper WA

更新日期：2018-06-15 00:00:00

abstract：OBJECTIVE:To review the current published literature on the use of procalcitonin as a diagnostic and prognostic marker in adult patients with meningitis. METHODS:We conducted a PubMed search to identify all relevant publications regarding the diagnostic and prognostic value of serum procalcitonin in patients with a kn...

journal_title：Journal of clinical medicine

authors： Velissaris D,Pintea M,Pantzaris N,Spatha E,Karamouzos V,Pierrakos C,Karanikolas M

更新日期：2018-06-11 00:00:00

abstract：:In the past, numerous non-operative treatments for adolescent idiopathic scoliosis (AIS), including exercise, physical therapy, electrical stimulation, and brace treatment, have been tried to delay or prevent the curve progression. Of these, brace treatment is the only option that is widely accepted and has demonstrat...

journal_title：Journal of clinical medicine

authors： Kuroki H

更新日期：2018-06-04 00:00:00

abstract：:Social media enables the public sharing of information. With the recent emphasis on transparency and the open sharing of information between doctors and patients, the intersection of social media and healthcare is of particular interest. Twitter is currently the most popular form of social media used for healthcare co...

journal_title：Journal of clinical medicine

authors： Pershad Y,Hangge PT,Albadawi H,Oklu R

更新日期：2018-05-28 00:00:00

abstract：:We report the case of a 21-year old woman presenting with high blood pressure and raised normetanephrine levels. Indium-111-pentetreotide single photon-emission computed tomography with computed tomography (SPECT/CT) and 2-deoxy-2-[fluorine-18]fluoro-d-glucose (FDG) positron emission tomography/computed tomography (PE...

journal_title：Journal of clinical medicine

authors： Bahougne T,Romanet P,Mohamed A,Caselles K,Cuny T,Barlier A,Niccoli P

更新日期：2018-05-23 00:00:00

abstract：:There is a lack of evidence or societal guidelines regarding the utility of fibrinogen monitoring during thrombolysis. The purpose of our study was to investigate the current use of monitoring fibrinogen levels during thrombolysis. A voluntary, anonymous online survey was sent to all physician members of the Society o...

journal_title：Journal of clinical medicine

authors： Kaufman C,Kinney T,Quencer K

更新日期：2018-05-10 00:00:00

abstract：:Postoperative ileus is one of the most important and common complications after abdominal surgery. This single-blind randomized clinical trial study was conducted with the aim of evaluating the effect of oral pyridostigmine (60 mg) on the duration and frequency of response to the treatment of ileus after abdominal sur...

journal_title：Journal of clinical medicine

authors： Maleknejad A,Khazaei A,Bouya S

更新日期：2018-05-06 00:00:00

abstract：:Current therapy of Clostridium difficile diarrhea (CDD) is problematic. Optimal treatment for CDD remains oral vancomycin, but there is little data on oral vancomycin dosing regimens. The objective of this C. difficile diarrhea study was to compare the efficacy of "high dose" vancomycin, 500 mg (PO) q6h, as sole treat...

journal_title：Journal of clinical medicine

authors： Cunha BA,Sessa J,Blum S

更新日期：2018-04-10 00:00:00

abstract：:Androgens are essential for the development, differentiation, growth, and function of the prostate through epithelial-stromal interactions. However, androgen concentrations in the hypertrophic human prostate decrease significantly with age, suggesting an inverse correlation between androgen levels and proliferative di...

journal_title：Journal of clinical medicine

authors： Ishii K,Takahashi S,Sugimura Y,Watanabe M

更新日期：2018-04-02 00:00:00

abstract：:Mitochondrial respiratory chain (MRC) disorders have a multifaceted clinical presentation and genetic origin[...]. ...

journal_title：Journal of clinical medicine

authors： Hargreaves IP

更新日期：2018-03-29 00:00:00

abstract：:The aim of this article is to investigate pathological subjects from a population through different physical factors. To achieve this, particle swarm optimization (PSO) and K-means (KM) clustering algorithms have been combined (PSO-KM). Datasets provided by the literature were divided into three clusters based on age ...

journal_title：Journal of clinical medicine

authors： Sari M,Tuna C,Akogul S

更新日期：2018-03-28 00:00:00

abstract：:Bruton's tyrosine kinase (BTK) is a critical terminal enzyme in the B-cell antigen receptor (BCR) pathway. BTK activation has been implicated in the pathogenesis of certain B-cell malignancies. Targeting this pathway has emerged as a novel target in B-cell malignancies, of which ibrutinib is the first-in-class agent. ...

journal_title：Journal of clinical medicine

authors： Campbell R,Chong G,Hawkes EA

更新日期：2018-03-21 00:00:00

abstract：:This study investigated associations of perceived environmental factors with leisure-time physical activity (LTPA) and screen time (ST) among older adults. A cross-sectional study was conducted by administering computer-assisted telephone interviews to 1028 older Taiwanese adults in November 2016. Data on personal fac...

journal_title：Journal of clinical medicine

authors： Hsueh MC,Lin CY,Huang PH,Park JH,Liao Y

更新日期：2018-03-13 00:00:00

abstract：:Organ transplantation is a new issue in medical science. It is an important achievement and a sign of the progression and ability of medical centers around the world. Governments, populations, the medical community and people involved in culture, art, and media all have a decisive role in the culture of organ donation...

journal_title：Journal of clinical medicine

authors： Kiani M,Abbasi M,Ahmadi M,Salehi B

更新日期：2018-03-05 00:00:00

abstract：:Thyroid follicular cells, as well as adrenocortical cells, are endowed by an intrinsic heterogeneity regarding their growth potential, in response to various stimuli. This heterogeneity appears to constitute the underlying cause for the focal cell hyperplasia and eventually the formation of thyroid and adrenal nodules...

journal_title：Journal of clinical medicine

authors： Tsatsoulis A

更新日期：2018-02-26 00:00:00

abstract：:With this Editorial we want to present the Special Issue "Big Data and Precision Medicine Series I: Lung Cancer Early Diagnosis" to the scientific community, which aims to gather experts on the early detection of lung cancer in order to implement common efforts in the fight against cancer. ...

journal_title：Journal of clinical medicine

authors： Gasparri R,Sedda G,Spaggiari L

更新日期：2018-02-09 00:00:00

abstract：:In addition to its regulatory function in the formation of red blood cells (erythropoiesis) in vertebrates, Erythropoietin (Epo) contributes to beneficial functions in a variety of non-hematopoietic tissues including the nervous system. Epo protects cells from apoptosis, reduces inflammatory responses and supports re-...

journal_title：Journal of clinical medicine

authors： Ostrowski D,Heinrich R

更新日期：2018-02-02 00:00:00

abstract：:(1) Background: This study evaluated the perioperative red blood cell (RBC) transfusion need and determined predictors for transfusion in patients undergoing elective primary lumbar posterior spine fusion in a high-volume center for spine surgery. (2) Methods: Data from all patients undergoing spine surgery between 1 ...

journal_title：Journal of clinical medicine

authors： Ristagno G,Beluffi S,Tanzi D,Belloli F,Carmagnini P,Croci M,D'Aviri G,Menasce G,Pastore JC,Pellanda A,Pollini A,Savoia G

更新日期：2018-01-30 00:00:00

abstract：:The radial nerve is the most frequently injured nerve in the upper extremity. Numerous options in treatment have been described for radial nerve injury, such as neurolysis, nerve grafts, or tendon transfers. Currently, new treatment options are arising, such as platelet-rich plasma (PRP), an autologous product with pr...

journal_title：Journal of clinical medicine

authors： García de Cortázar U,Padilla S,Lobato E,Delgado D,Sánchez M

更新日期：2018-01-29 00:00:00

abstract：:Increased the incidence of prediabetes and type 2 diabetes (T2D) worldwide raises an urgent need to develop effective tools for early disease detection to facilitate future preventive interventions and improve patient's care. We evaluated the suitability of diabetes-related miR-375 and miR-9 as earlier biomarkers for ...

journal_title：Journal of clinical medicine

authors： Al-Muhtaresh HA,Al-Kafaji G

更新日期：2018-01-26 00:00:00

abstract：:Diabetes in pregnancy, both preexisting type 1 or type 2 and gestational diabetes, is a highly prevalent condition, which has a great impact on maternal and fetal health, with short and long-term implications. Gestational Diabetes Mellitus (GDM) is a condition triggered by metabolic adaptation, which occurs during the...

journal_title：Journal of clinical medicine

authors： Carreiro MP,Nogueira AI,Ribeiro-Oliveira A

更新日期：2018-01-25 00:00:00

abstract：:Irritable bowel syndrome (IBS) is one of the most common of all medical disorders worldwide and, while for some it represents no more than a nuisance, for others it imposes significant negative impacts on daily life and activities. IBS is a heterogeneous disorder and may well have a number of causes which may lie anyw...

journal_title：Journal of clinical medicine

authors： Quigley EMM

更新日期：2018-01-03 00:00:00

abstract：:Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder, with the characteristic symptoms of chronic abdominal pain and altered bowel habits (diarrhea, constipation, or both). IBS is a highly prevalent condition, which negatively affects quality of life and is a significant burden on global healthcare...

journal_title：Journal of clinical medicine

authors： Asano T,Takenaga M

更新日期：2017-11-03 00:00:00

abstract：:Irritable bowel syndrome (IBS) is a disorder of the brain-gut axis; the pathophysiological mechanisms include altered colonic motility, bile acid metabolism, neurohormonal regulation, immune dysfunction, alterations in the epithelial barrier and secretory properties of the gut. This article reviews the mechanisms, eff...

journal_title：Journal of clinical medicine

authors： Camilleri M,Ford AC

更新日期：2017-10-27 00:00:00

abstract：:Oxidative stress arises when cellular antioxidant defences become overwhelmed by a surplus generation of reactive oxygen species (ROS). Once this occurs, many cellular biomolecules such as DNA, lipids, and proteins become susceptible to free radical-induced oxidative damage, and this may consequently lead to cellular ...

journal_title：Journal of clinical medicine

authors： Al Shahrani M,Heales S,Hargreaves I,Orford M

更新日期：2017-10-27 00:00:00

abstract：BACKGROUND:Despite growing social acceptance, the LGBTQ population continues to face barriers to healthcare including fear of stigmatization by healthcare providers, and providers' lack of knowledge about LGBTQ-specific health issues. This analysis focuses on the assessment of quantitative and qualitative responses fro...

journal_title：Journal of clinical medicine

authors： Tamargo CL,Quinn GP,Sanchez JA,Schabath MB

更新日期：2017-10-07 00:00:00

abstract：:C-reactive protein (CRP) and myxovirus resistance protein A (MxA) are associated with bacterial and viral infections, respectively. We conducted a prospective, multicenter, cross-sectional study of adults and children with febrile upper respiratory tract infections (URIs) to evaluate the diagnostic accuracy of a rapid...

journal_title：Journal of clinical medicine

authors： Self WH,Rosen J,Sharp SC,Filbin MR,Hou PC,Parekh AD,Kurz MC,Shapiro NI

更新日期：2017-10-07 00:00:00

abstract：:Multiple myeloma (MM) is a hematological malignancy with a poor prognosis, characterized by clonal proliferation of plasma cells in the bone marrow (BM). Relapse due to undetected minimal residual disease (MRD) is the leading cause of death among patients with MM. This review summarizes the methods and prognostic valu...

journal_title：Journal of clinical medicine

authors： Takamatsu H

更新日期：2017-09-25 00:00:00

abstract：:Clinically, in young immunocompetent adults, Epstein-Barr virus (EBV) usually manifests as infectious mononucleosis (IM). Typical clinical findings of EBV IM include fever, profound fatigue, pharyngitis, bilateral posterior cervical adenopathy, and splenomegaly. Respiratory involvement with EBV IM may occur, but is di...

journal_title：Journal of clinical medicine

authors： Cunha BA,Herrarte Fornos S

更新日期：2017-09-04 00:00:00

abstract：:Joint bleeding represents the most commonly reported type of hemorrhage in patients affected by hemophilia. Although the widespread use of prophylaxis has been able to significantly reduce the onset of arthropathy, it has been shown that a non-negligible percentage of patients develop degenerative changes in their joi...

journal_title：Journal of clinical medicine

authors： Di Minno MND,Pasta G,Airaldi S,Zaottini F,Storino A,Cimino E,Martinoli C

更新日期：2017-07-31 00:00:00

abstract：:Rheumatoid arthritis (RA) is a systemic autoimmune disease, caused by both genetic and environmental factors. Recently, investigators have focused on the gut microbiota, which is thought to be an environmental agent affecting the development of RA. Here we review the evidence from animal and human studies that support...

journal_title：Journal of clinical medicine

authors： Maeda Y,Takeda K

更新日期：2017-06-09 00:00:00

abstract：:Minimal residual disease evaluation refers to a series of molecular and immunophenotypical techniques aimed at detecting submicroscopic disease after therapy. As such, its application in acute myeloid leukemia has greatly increased our ability to quantify treatment response, and to determine the chemosensitivity of th...

journal_title：Journal of clinical medicine

authors： Mosna F,Capelli D,Gottardi M

更新日期：2017-06-03 00:00:00

abstract：:Hemophilia is the most common of the severe bleeding disorders and if not properly managed since early infancy can lead to chronic disease and lifelong disabilities. However, it enjoys the most efficacious and safe treatment among the most prevalent monogenic disorders. Hemophilia should be considered in the neonatal ...

journal_title：Journal of clinical medicine

authors： Bertamino M,Riccardi F,Banov L,Svahn J,Molinari AC

更新日期：2017-05-19 00:00:00

abstract：:Conventional angiography is used to evaluate and treat possible sources of intraabdominal bleeding, though it may cause complications such as contrast-induced nephropathy (CIN). The study's purpose was to identify factors predicting active extravasation and complications during angiography for acute intraabdominal ble...

journal_title：Journal of clinical medicine

authors： Haber ZM,Charles HW,Erinjeri JP,Deipolyi AR

更新日期：2017-04-18 00:00:00

abstract：:Significant others are often crucial for suicidal persons or suicide attempters' access to care, yet little is known about their efforts to seek help. This article presents the findings of a qualitative pilot study carried out in Switzerland on the help-seeking process of 18 significant others, their perception of the...

journal_title：Journal of clinical medicine

authors： Castelli Dransart DA,Guerry S

更新日期：2017-02-13 00:00:00